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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TIAM2 All Species: 5.76
Human Site: S261 Identified Species: 18.1
UniProt: Q8IVF5 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IVF5 NP_001010927.1 1701 190113 S261 W G N A G E L S E A E G S F L
Chimpanzee Pan troglodytes XP_527545 1701 190152 S261 W G N A G E L S E A E G S F L
Rhesus Macaque Macaca mulatta XP_001098107 1591 177452 E215 C E E A R G M E T R A S P R Q
Dog Lupus familis XP_541162 1487 166908 G110 G A R L A P A G L R L P H D F
Cat Felis silvestris
Mouse Mus musculus Q6ZPF3 1715 192548 E259 G N A G E V S E V E G S F L A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419687 1705 192295 I261 L W G N A G D I S E L D G P Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91620 2061 229913 S507 R S C A P L L S C R N R K C L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_788791 1150 129570
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 38.9 78.3 N.A. 83.7 N.A. N.A. N.A. 77.9 N.A. N.A. N.A. 26.4 N.A. N.A. 24.6
Protein Similarity: 100 99.4 56.5 81.5 N.A. 89.1 N.A. N.A. N.A. 86.6 N.A. N.A. N.A. 41.8 N.A. N.A. 39.8
P-Site Identity: 100 100 6.6 0 N.A. 0 N.A. N.A. N.A. 0 N.A. N.A. N.A. 26.6 N.A. N.A. 0
P-Site Similarity: 100 100 13.3 0 N.A. 0 N.A. N.A. N.A. 0 N.A. N.A. N.A. 26.6 N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 13 50 25 0 13 0 0 25 13 0 0 0 13 % A
% Cys: 13 0 13 0 0 0 0 0 13 0 0 0 0 13 0 % C
% Asp: 0 0 0 0 0 0 13 0 0 0 0 13 0 13 0 % D
% Glu: 0 13 13 0 13 25 0 25 25 25 25 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 13 25 13 % F
% Gly: 25 25 13 13 25 25 0 13 0 0 13 25 13 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % H
% Ile: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % K
% Leu: 13 0 0 13 0 13 38 0 13 0 25 0 0 13 38 % L
% Met: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % M
% Asn: 0 13 25 13 0 0 0 0 0 0 13 0 0 0 0 % N
% Pro: 0 0 0 0 13 13 0 0 0 0 0 13 13 13 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % Q
% Arg: 13 0 13 0 13 0 0 0 0 38 0 13 0 13 0 % R
% Ser: 0 13 0 0 0 0 13 38 13 0 0 25 25 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 13 0 0 13 0 0 0 0 0 0 % V
% Trp: 25 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _